Ashkhen Yesayan, Aleksandr Grabski, Farzan Jazaeri, Jean-Michel Sallese
Design-Oriented Analytical Model for Nanowire Biosensors Including Dynamic Aspects
IEEE TED (2025) DOI 10.1109/TED.2025.3526113
Abstract: Nanowire Field Effect Transistor (NWFET) biosensors are known to be highly sensitivity devices that can detect extremely low concentrations of biomolecules. In this paper, we present an analytical model alongside with numerical simulations to calculate the sensitivity of NWFET biosensors. The model accounts for biosensing dynamics as well as diffusion of ions in the solution and across the functionalized layer. The signal-to-noise ratio is also estimated, which gives a lower limit in terms of sensitivity. The model is physics based and is validated against a commercial multiphysics simulations and experimental data. It predicts the bio-sensitivity down to femtomolar concentration of biomolecules without any fitting parameter.
FIG: Schematic structure of device (a), the charge distribution in theoretical model (b)
and Si NWFET sensitivity simulated with presented model (c)
Acknowledgement: This work was supported by the Science Committee of RA, in the frames of the research project No:21T-2B321.
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